Bryson D. Bennett

This study shows that GIMAP6 loss leads to inflammatory vasculopathy and atherosclerosis, causing heart failure and early death, and identifies GIMAP6 as a protective factor against cardiovascular disease.

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

This study identifies molecular changes in diet-restricted mice that correlate with lifespan and aging, highlighting key genes and pathways involved in longevity.

This study shows that disrupted electron transport chain function in yeast leads to failure in glucose derepression via the Snf1 pathway, affecting galactose metabolism.

This paper shows that an eIF2B activator rescues neonatal lethality in a VWM mouse model but leads to age-related motor deficits and myelin loss.

The paper describes an automated LLE platform for plasma sample preparation and analyzes metabolomic, lipidomic, and proteomic changes in mice on a high-fat diet.

The paper analyzes the multiome of Diversity Outbred mice to explore how aging and lifespan are related, finding that proteomic changes correlate with biological age rather than chronological age.

The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.

This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.