Adam Freund

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Age and diet shape the genetic architecture of body weight in Diversity Outbred mice

The paper quantifies diet-dependent genetic contributions to body weight in mice and identifies loci associated with age- and diet-dependent body weight variation.

Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

This study develops a high-dimensional phenotyping platform to evaluate physiological aging and resilience in mice, finding that aging begins early and resilience declines with age.

Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin

The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.

Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice

This study examines how caloric restriction and intermittent fasting interact with genetics to influence physiological health in mice, finding diet-specific effects and significant genetic contributions to multiple traits.