Jonathon J. O’Brien

The paper describes an automated LLE platform for plasma sample preparation and analyzes metabolomic, lipidomic, and proteomic changes in mice on a high-fat diet.

The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.

This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.

The paper shows that a novel eIF2B activator prevents neurological defects in a mouse model of Vanishing White Matter disease by normalizing the transcriptome and proteome.