V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is aPhenotypic Driver of Lysosome Dysfunction in Replicative Aging
This study shows that V-ATPase disassembly in yeast aging cells leads to lysosome dysfunction and shorter lifespan, which can be reversed by caloric restriction.
Aging Cell · Jan 16, 2025Peer-reviewedCell Biology