Patricia M. Kane

This paper identifies PI(3,5)P2 as a key lipid signaling molecule that drives early vacuolar responses to hyperosmotic stress in yeast, linking lipid synthesis to V-ATPase activity and salt sequestration.

This study identifies Mdm38/LETM1 as a protein that links ion homeostasis and proteostasis in the mitochondrial inner membrane in yeast.

This study shows that V-ATPase disassembly in yeast aging cells leads to lysosome dysfunction and shorter lifespan, which can be reversed by caloric restriction.

The paper determines the structure of yeast RAVE bound to a partial V1 complex using cryo-EM, revealing its role in facilitating V1-VO reassociation.

The paper identifies genetic determinants of chemical resistance in yeast using in vitro evolution and whole genome sequencing, revealing key transcription factors involved in drug resistance.