Polygenic Risk for Skin Autoimmunity Impacts Immune Checkpoint Blockade in Bladder Cancer
Zia Khan, Flavia Di Nucci, Antonia Kwan, Christian Hammer, Sanjeev Mariathasan, Vincent Rouilly, Jonathan Carroll, Magnus Fontes, Sergio Ley Acosta, Ellie Guardino, Haiyin Chen‐Harris, Tushar Bhangale, Ira Mellman, Jonathan E. Rosenberg, Thomas B. Powles, , Matthew L. Albert
The paper shows that polygenic risk scores for skin autoimmunity affect the response to immune checkpoint blockade in bladder cancer, with higher vitiligo and psoriasis scores linked to better outcomes.
Proceedings of the National Academy of Sciences · May 19, 2020Peer-reviewedGenetics