Zia Khan

The Alzheimers Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states

This study shows that MS4A4A and MS4A6A negatively regulate TREM2 and microglial function in Alzheimer's disease, suggesting they are potential drug targets.

Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genes

The paper uses CRISPR screens and Perturb-seq to identify gene programs and functional relationships in AD GWAS risk genes related to lipid and lysosomal pathways.

Enhancing Gene Set Overrepresentation Analysis with Large Language Models

This paper introduces llm2geneset, a framework using large language models to generate gene sets from input genes and context, improving overrepresentation analysis compared to human-curated databases.

Germline variants associated with immunotherapy-related adverse events

This study identifies three germline variants associated with immune-related adverse events in patients treated with immune checkpoint inhibitors.

Polygenic Risk for Skin Autoimmunity Impacts Immune Checkpoint Blockade in Bladder Cancer

The paper shows that polygenic risk scores for skin autoimmunity affect the response to immune checkpoint blockade in bladder cancer, with higher vitiligo and psoriasis scores linked to better outcomes.

A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes

This study assesses genetic influences on inter-individual variation in three human phosphoproteomes and identifies genetic associations with phosphopeptide variation.