Ira Mellman

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

The paper identifies tumor-reactive T cells by focusing on productive T-cell engagement with tumor cells, showing that such interactions enrich for neoantigen-reactive clonotypes with progenitor-like states.

This study shows that repeated RNA-lipoplex vaccination sustains functional CD8 T cells in tumors and improves therapeutic outcomes.

The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.

This study identifies spatially organized cDC1-T cell clusters within tumors as critical for enhancing CTL-mediated tumor rejection through local costimulation.

This paper evaluates machine learning approaches for predicting T-cell receptor specificity, highlighting limitations in current data and methods, and proposes a new framework integrating biophysical measurements.

This study identifies HLA-DRB1 and HLA-DQA1 alleles associated with anti-drug antibodies and neutralizing antibodies in atezolizumab-treated cancer patients.

The paper shows that polygenic risk scores for skin autoimmunity affect the response to immune checkpoint blockade in bladder cancer, with higher vitiligo and psoriasis scores linked to better outcomes.