A STAT3-regulated lncRNA integrates microRNA biogenesis and sequestration to safeguard naive pluripotency
Vincent Giudice, Florence Perold, Yannicke Pijoff, Nathalie Doerflinger, Nicolas Allègre, Claire Chazaud, Irène Aksoy, Pierre Savatier, Pierre-Yves Bourillot
The paper identifies Asgard, a STAT3-regulated lncRNA, which controls microRNA biogenesis and sequestration to maintain naive pluripotency in mouse embryonic stem cells.
bioRxiv · Sep 23, 2025 · PreprintDevelopmental Biology