This study shows Netrin-1 supports naive pluripotency in hESCs by modulating epigenetic and signaling pathways, with effects dependent on culture conditions.

bioRxiv · Jul 16, 2026 · PreprintCell Biology

A ligand/receptor trafficking clock governs self-renewal and abscission dynamics in pluripotent stem cells

Debora Libetti, Noémie Combémorel, Emma Fraimbault, Marie Lantelme, Xavier Gaume, Emile Zakiev, Yann Tapponnier, Aurélia Huyghe, Giacomo Furlan, Marion Coudurier, Léo Claret, Cloé Rognard, Serife Akguel, Serife Akguel, Hector Hernandez-vargas, , Fabrice Lavial

The paper identifies a ligand/receptor trafficking clock in pluripotent stem cells that regulates self-renewal and abscission dynamics through cyclic turnover of Netrin-1 and its receptors.

bioRxiv · Dec 23, 2025 · PreprintCell Biology

A STAT3-regulated lncRNA integrates microRNA biogenesis and sequestration to safeguard naive pluripotency

Vincent Giudice, Florence Perold, Yannicke Pijoff, Nathalie Doerflinger, Nicolas Allègre, Claire Chazaud, Irène Aksoy, Pierre Savatier, Pierre-Yves Bourillot

The paper identifies Asgard, a STAT3-regulated lncRNA, which controls microRNA biogenesis and sequestration to maintain naive pluripotency in mouse embryonic stem cells.

bioRxiv · Sep 23, 2025 · PreprintDevelopmental Biology

Identification of novel candidate regulators of human naive pluripotency by means of a genetic switch utilizing the chimeric receptor G-CSFR:GP130

Tahereh Kiani, Claire Santamaria, Nathalie Doerflinger, Aikaterini Kafousi, Cloé Rognard, Ambre Bender, Michaël Dumas, Michaël Weber, Alexandre Bruneau, Laurent David, Pierre Savatier, Pierre-Yves Bourillot

This study identifies novel regulators of human naive pluripotency using a genetic switch that activates STAT3 and JAK signaling, revealing key genes and mechanisms involved in reprogramming.

bioRxiv · Apr 9, 2025 · PreprintCell Biology

Extensive remodelling of XIST regulatory networks during primate evolution

Emmanuel Cazottes, Charbel Alfeghaly, Cloé Rognard, Agnese Loda, Gaël Castel, Laura Villacorta, Michael X. Dong, Édith Heard, Irène Aksoy, Pierre Savatier, Céline Morey, Claire Rougeulle

The paper examines how XIST regulatory networks evolve in primates, showing extensive diversification and the role of transposons and enhancers in different species.

bioRxiv · Dec 4, 2023 · PreprintGenomics

Major transcriptomic, epigenetic and metabolic changes underly the pluripotency continuum in rabbit preimplantation embryos

Wilhelm Bouchereau, Luc Jouneau, Catherine Archilla, Irène Aksoy, Anaïs Moulin, Nathalie Daniel, Nathalie Peynot, Sophie Caldérari, Thierry Joly, Murielle Godet, Yan Jaszczyszyn, Marine Pratlong, Dany Séverac, Pierre Savatier, Véronique Duranthon, , Nathalie Beaujean

This study maps the transcriptomic, epigenetic, and metabolic changes in rabbit preimplantation embryos, identifying novel markers of naive pluripotency and similarities to human and primate embryos.

Development · Aug 22, 2022Peer-reviewedDevelopmental Biology

Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: a Longitudinal Study in a Macaque Model of Parkinson's Disease

Florence Wianny, Kwamivi Dzahini, Karim Fifel, Charles R. E. Wilson, Agnieszka Bernat, Virginie Dolmazon, Pierre Misery, Camille Lamy, Pascale Giroud, Howard Michael Cooper, Kenneth Knoblauch, Emmanuel Procyk, Henry Kennedy, Pierre Savatier, Colette Dehay, Julien Vezoli

This study shows that grafts of neural precursors reverse cognitive and motor symptoms in a non-human primate model of Parkinson's disease.

Advanced Science · Feb 9, 2022Peer-reviewedNeuroscience