Tuning T-cell immunological synapse by modular DNA-Nanobody engagers for precision immunotherapy
Juliette Prothon, Gaurav Verma, Beatriz Díaz-Bello, Martine Biarnes‐Pelicot, Florian Dupuy, Charlie Gosse, Gaëtan Bellot, Kheya Sengupta, Laurent Limozin, Patrick Chames
This paper designs modular DNA-Nanobody engagers to tune T-cell immunological synapses for precision immunotherapy, showing linker-length effects on cytotoxicity and cytokine release.
bioRxiv · Jul 23, 2026 · PreprintSynthetic Biology