Laurent Limozin

This study shows degranulation in T cells is regulated by physical and chemical factors, with insoluble particles transported directionally and CAR T cells having impaired particle centralization.

This paper designs modular DNA-Nanobody engagers to tune T-cell immunological synapses for precision immunotherapy, showing linker-length effects on cytotoxicity and cytokine release.

Celldetective is an AI-enhanced image analysis tool for analyzing dynamic cell interactions in immunology and immunotherapy assays.

The paper investigates antibody maturation in germinal centers, finding that mechanical resistance of BCR-antigen bonds, not affinity, drives selection during maturation.

The paper measures cytotoxicity of bispecific antibodies using NK cells and introduces a model to decouple host response from engager characteristics.

This study measures antigen-antibody bond behavior under force using nanobodies and flow chamber assays, revealing catch bond properties and NK cell mechanosensitivity.