Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle
Ruzbeh Mosadeghi, Kurt M Reichermeier, Martin Winkler, Anne Schreiber, Justin M Reitsma, Yaru Zhang, Florian Stengel, Junyue Cao, Minsoo Kim, Michael J Sweredoski, Sonja Hess, Alexander Leitner, Ruedi Aebersold, Matthias Peter, Raymond J Deshaies, Radolsav I Enchev
The paper identifies structural and kinetic mechanisms of COP9-Signalosome activation and Nedd8 deconjugation in cullin-RING ubiquitin ligase deneddylation.
eLife · Mar 31, 2016Peer-reviewedBiochemistry