Author

Ruedi Aebersold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Systems Biology· 2 Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Research Focus:benchmarking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Alexander LeitneriD· 2 shared Florian Stengel· 2 shared Abdellah Allali-Hassani· 1 shared Albert J. R. HeckiD· 1 shared Alex ZelteriD· 1 shared Alexander Lemak· 1 shared Andrea SinziD· 1 shared Anne Schreiber· 1 shared

Activity by Year

2016-2018 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

Alexander LeitnerORCID

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Author profile →

7 papers

Recent·Most cited

Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines

Claudio Iacobucci, Christine Piotrowski, Ruedi Aebersold, Bruno C. Amaral, Philip Andrews, Christoph Borchers, Nicolas I. Brodie, James E. Bruce, Stéphane Chaignepain, Juan D. Chavez, Stéphane Claverol, Jürgen Cox, Gianluca Degliesposti, Meng-Qiu Dong, Nufar Edinger, , Andrea Sinz

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.

bioRxiv · Sep 26, 2018 · PreprintBiochemistry

MLL1 minimal catalytic complex is a dynamic conformational ensemble susceptible to pharmacological allosteric disruption

Lilia Kaustov, Alexander Lemak, Hong Wu, Marco Faini, Scott Houliston, Lixin Fan, Xianyang Fang, Hong Zeng, Shili Duan, Abdellah Allali-Hassani, Masoud Vedadi, Ruedi Aebersold, Yunxing Wang, Cheryl H. Arrowsmith

The paper investigates the dynamic structure of the MLL1 catalytic complex and shows it can be disrupted by pharmacological agents targeting specific interaction sites.

bioRxiv · Apr 26, 2018 · PreprintBiophysics

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

Ben C Collins, Christie L Hunter, Yansheng Liu, Birgit Schilling, George Rosenberger Rosenberger, Samuel L Bader, Daniel W Chan, Bradford W Gibson, Anne-Claude Gingras, Jason M Held, Mio Hirayama-Kurogi, Guixue Hou, Christoph Krisp Krisp, Brett Larsen, Liang Lin, , Ruedi Aebersold

This study evaluates SWATH-MS across 11 labs, showing consistent detection and quantification of over 4,000 proteins with reproducible quantitative data.

bioRxiv · Sep 14, 2016Biochemistry

A high density map for navigating the human Polycomb complexome

Simon Hauri, Federico Comoglio, Makiko Seimiya, Moritz Gerstung, Timo Glatter, Klaus Hansen, Ruedi Aebersold, Renato Paro, Matthias Gstaiger, Christian Beisel

This study maps the human Polycomb complexome using AP-MS, revealing new PcG complex interactions and distinct target gene binding by PR-DUB and PRC1 complexes.

bioRxiv · Jul 7, 2016Systems Biology

System-wide quantitative proteomics of the metabolic syndrome in mice: genotypic and dietary effects

Camille Terfve, Eduard Sabido, Yibo Wu, Emanuel Goncalves, Meena Choi, Stefania Vaga, Olga Vitek, Julio Saez-Rodriguez, Ruedi Aebersold

This study uses proteomics to analyze metabolic syndrome in mice, showing differential molecular adaptations to dietary and genetic factors.

bioRxiv · May 12, 2016Systems Biology

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

Ruzbeh Mosadeghi, Kurt M Reichermeier, Martin Winkler, Anne Schreiber, Justin M Reitsma, Yaru Zhang, Florian Stengel, Junyue Cao, Minsoo Kim, Michael J Sweredoski, Sonja Hess, Alexander Leitner, Ruedi Aebersold, Matthias Peter, Raymond J Deshaies, Radolsav I Enchev

The paper identifies structural and kinetic mechanisms of COP9-Signalosome activation and Nedd8 deconjugation in cullin-RING ubiquitin ligase deneddylation.

eLife · Mar 31, 2016Peer-reviewedBiochemistry

Automated SWATH Data Analysis Using Targeted Extraction of Ion Chromatograms

Hannes L Röst, Ruedi Aebersold, Olga T Schubert

This paper describes a protocol for automated SWATH MS data analysis, including manual and automated workflows for quality control and error rate control.

bioRxiv · Mar 19, 2016Bioinformatics