Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus
Junning Yang, Claire Simonneau, Robert Kilker, Laura Oakley, Matthew D. Byrne, Zuzana Nichtová, Ioana Stefanescu, Fnu Pardeep‐Kumar, Sushil Tripathi, Eric R. Londin, Pascale Saugier-Véber, Belinda B. Willard, Mathew L. Thakur, Stephen Pickup, Hiroshi Ishikawa, , Arie Horowitz
This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.
EMBO Molecular Medicine · Dec 5, 2018Peer-reviewedNeuroscience