Matthew D. Byrne

This paper delivers (G4C2)149 repeats intrathecally in C9orf72-deficient mice, revealing mild motor dysfunction and ALS/FTD pathological features.

This study shows that monomeric alpha-synuclein induces inflammation and dopamine neuron death in A53T SNCA mice, suggesting a mechanism for PD in humans with SNCA mutations.

This study shows that SARS-CoV-2 infection increases susceptibility to MPTP-induced parkinsonism in hACE2 mice, with greater dopaminergic neuron loss when combined with MPTP.

This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.