Author

Stephen Pickup

University of PennsylvaniaORCID 0000-0002-7016-8648Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:imaging· 4 Organism:mouse· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Carlos de la Rosa‐PrietoiD· 2 shared Cynthia J. ClendeniniD· 2 shared Daniel T. OhmiD· 2 shared David A. WolkiD· 2 shared David John IrwiniD· 2 shared Edward B. LeeiD· 2 shared Emilio Artacho‐PérulaiD· 2 shared Emma Elizabeth FurthiD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Carlos de la Rosa‐PrietoORCID

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Author profile →

5 papers

Recent·Most cited

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II

HL Tucker, Bradley G. Karat, AT De Ruiter, Dana M. Parker, Sydney Lim, AE Denning, Ranjit Ittyerah, Lisa M Levorse, Winifred Trotman, Alejandra Bahena, Eunice P. Chung, Karthik Prabhakaran, Madigan L. Bedard, Daniel T. Ohm, Long Xie, , LEM Wisse

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

bioRxiv · Nov 21, 2025 · PreprintNeuroscience

Multimetric MRI Captures Early Response and Acquired Resistance of Pancreatic Cancer to KRAS Inhibitor Therapy

Mamta Gupta, Hoon Choi, Samantha B. Kemp, Emma Elizabeth Furth, Stephen Pickup, Cynthia J. Clendenin, Margo Orlen, Mark Rosen, Fang Liu, Quy Cao, Ben Z. Stanger, Rong Zhou

Clinical Cancer Research · Apr 21, 2025Peer-reviewedCancer Biology

Effect of Stroma-directed Drugs in Combination with Chemotherapy Against Pancreatic Cancer- a Preclinical Study

Mamta Gupta, Hoon Choi, Emma Elizabeth Furth, Sydney M. Shaffer, Stephen Pickup, Cynthia J. Clendenin, Fang Liu, Quy Cao, Hee Kwon Song, Yong Fan A, Jeffrey Duda, James C. Gee, Thomas Benjamin Karasic, Mark Alan Rosen, Peter O’Dwyer, Rong Zhou

This study compares chemotherapy with and without stroma-directed drugs in a mouse model of pancreatic cancer, finding enhanced tumor growth inhibition and changes in tumor microenvironment.

bioRxiv · Dec 24, 2024 · PreprintCancer Biology

3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe

Paul A. Yushkevich, Mónica Muñoz, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Alex Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, , Ricardo Insausti

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.

bioRxiv · Jan 15, 2021 · PreprintNeuroscience

Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus

Junning Yang, Claire Simonneau, Robert Kilker, Laura Oakley, Matthew D. Byrne, Zuzana Nichtová, Ioana Stefanescu, Fnu Pardeep‐Kumar, Sushil Tripathi, Eric R. Londin, Pascale Saugier-Véber, Belinda B. Willard, Mathew L. Thakur, Stephen Pickup, Hiroshi Ishikawa, , Arie Horowitz

This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.

EMBO Molecular Medicine · Dec 5, 2018Peer-reviewedNeuroscience