Author

Claire Simonneau

F. Hoffmann-La Roche AG

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Alex OdermattiD· 2 shared Chiara Zanini· 2 shared Christelle Zundel· 2 shared Luisa Bell· 2 shared Nadine Stokar‐RegenscheitiD· 2 shared Roberto VillaseñoriD· 2 shared A. Rizkallah· 1 shared Aman Padamsey· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Alex OdermattORCID

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Author profile →

4 papers

Recent·Most cited

Spatial architecture of complex antibody formats dictates pharmacokinetics via FcRn-recycling

Stefan C Weise, Cordula Jany, Sabine Imhof-Jung, Claire Simonneau, Johannes Fraidling, Anna-Lena Bolender, Aman Padamsey, Elisa Di Lenarda, Anne Christine Cascais, Thomas Emrich, Tilman Schlothauer, Annette Indlekofer, Hubert Kettenberger, Volker Haucke, Wolfgang F. Richter, Thomas E. Kraft

This study shows how antibody structure affects FcRn recycling and pharmacokinetics, finding that invertbody design reduces clearance by threefold.

bioRxiv · Nov 4, 2026 · PreprintPharmacology & Toxicology

ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells

Luisa Bell, Shane Clerkin, Filiz Sila Rizalar, A. Rizkallah, Nadine Stokar‐Regenscheit, Xandor M. Spijkers, Nienke R. Wevers, Claire Simonneau, Angélique Augustin, Barbara Höllbacher, Lia D’Abate, Joanna Ficek, Kim Schneider, Désirée von Tell, Thomas L. Maurissen, , Roberto Villaseñor

The paper investigates how ApoE4 affects intracellular trafficking and iron homeostasis in human brain endothelial cells derived from iPSCs, showing altered endosomal organization and iron levels.

Stem Cell Reports · Aug 21, 2025Peer-reviewedCell Biology

Advanced Tissue Technologies of Blood-Brain Barrier Organoids as High Throughput Toxicity Readouts in Drug Development

Luisa Bell, Claire Simonneau, Chiara Zanini, Elena Kassianidou, Christelle Zundel, Rachel Neff, Bernd Steinhuber, Marco Tecilla, Alex Odermatt, Roberto Villaseñor, Nadine Stokar‐Regenscheit

Paraffin histology, multiplex immunofluorescence and MALDI imaging work on blood-brain barrier organoids; an AI apoptosis detector on hematoxylin-eosin slides (F1 0.817 vs pathologists) tracked staurosporine dose responses.

Heliyon · Dec 2, 2024Peer-reviewedPathology✦ In-depth digest

Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus

Junning Yang, Claire Simonneau, Robert Kilker, Laura Oakley, Matthew D. Byrne, Zuzana Nichtová, Ioana Stefanescu, Fnu Pardeep‐Kumar, Sushil Tripathi, Eric R. Londin, Pascale Saugier-Véber, Belinda B. Willard, Mathew L. Thakur, Stephen Pickup, Hiroshi Ishikawa, , Arie Horowitz

This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.

EMBO Molecular Medicine · Dec 5, 2018Peer-reviewedNeuroscience