A Tissue Proteolysis Activity Mapping and Substrate Discovery Platform for Identifying Novel Tumor-Activated Biosensors
Itay Algov, Audrey E. Van Heest, Megan Hopton, Frances Liang, Aidan Holmes, Liangliang Hao, Xin X. Zhou
This paper introduces PSurf, a platform for identifying tissue-specific protease sensors, and demonstrates its use in detecting tumor-specific proteolytic activity in lung tissue.
Nature Chemical Biology · May 11, 2026Peer-reviewedBioengineering