Xin X. Zhou

This paper introduces PSurf, a platform for identifying tissue-specific protease sensors, and demonstrates its use in detecting tumor-specific proteolytic activity in lung tissue.

Z-TAC converts IgG antibodies into cell-surface protein degraders, enabling efficient and sustained degradation of multiple receptors and receptor combinations.

The paper introduces Sphyder, a tool to detect and rewire phosphorylation motifs, revealing PD-1 signaling mechanisms and enabling synthetic receptor design for immunotherapy.

This paper introduces GTACs, bispecific antibodies that selectively downregulate GPCRs via endocytosis and lysosomal degradation, showing high potency and selectivity for therapeutic targets.