Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis
Vincenza Valerio, Ilaria Massaiu, Matteo Franchi, Antoine Rimbert, Zoé Begué-Racapé, Mattia Chiesa, Veronika A. Myasoedova, Valentina Rusconi, Francesca Bertolini, Donato De Giorgi, Alice Bonomi, Sergio Pirola, Marco Zanobini, Paola Di Pietro, Albino Carrizzo, , Paolo Poggio
This study shows SIRT1 regulates calcific aortic valve stenosis progression and that SGLT2i may slow valve degeneration by modulating SIRT1.
Cardiovascular Research · Sep 5, 2026Peer-reviewedCell Biology