Author

Donato Moschetta

Centro Cardiologico MonzinoORCID 0000-0002-7746-8539Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Paolo PoggioiD· 2 shared Vincenza ValerioiD· 2 shared Andreas MartinssoniD· 1 shared Benoît J. ArsenaultiD· 1 shared Christian Dina CiD· 1 shared Donato De Giorgi· 1 shared Elvira MassiD· 1 shared Francesca Bertolini· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Paolo PoggioORCID

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2 papers

Recent·Most cited

Immortalization of human valve interstitial cells: an in vitro tool for studying fibro-calcific aortic valve degeneration

Donato Moschetta, Ilaria Massaiu, Francesca Bertolini, Vincenza Valerio, Valentina Rusconi, Donato De Giorgi, Veronika A. Myasoedova, Paolo Poggio

The paper immortalizes human valve interstitial cells to study fibro-calcific aortic valve degeneration and test drugs in vitro.

bioRxiv · Sep 26, 2024 · PreprintCell Biology

Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis

Nicolas Perrot, Donato Moschetta, S. Matthijs Boekholdt, Vincenza Valerio, Andreas Martinsson, Romain Capoulade, Elvira Mass, Marie-Annick A Clavel, Nicholas J. Wareham, Christian Dina C, Hao Yu Chen, James C. Engert, George Thanassoulis, Patrick Mathieu, Yohan Bossé, , Benoît J. Arsenault

This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.

bioRxiv · Mar 1, 2019 · PreprintGenetics