Author

Paolo Poggio

University of MilanORCID 0000-0002-7225-3379Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Vincenza ValerioiD· 3 shared Donato De Giorgi· 2 shared Donato MoschettaiD· 2 shared Francesca Bertolini· 2 shared Ilaria MassaiuiD· 2 shared Romain CapouladeiD· 2 shared Valentina Rusconi· 2 shared Veronika A. MyasoedovaiD· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

Vincenza ValerioORCID

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3 papers

Recent·Most cited

Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis

Vincenza Valerio, Ilaria Massaiu, Matteo Franchi, Antoine Rimbert, Zoé Begué-Racapé, Mattia Chiesa, Veronika A. Myasoedova, Valentina Rusconi, Francesca Bertolini, Donato De Giorgi, Alice Bonomi, Sergio Pirola, Marco Zanobini, Paola Di Pietro, Albino Carrizzo, , Paolo Poggio

This study shows SIRT1 regulates calcific aortic valve stenosis progression and that SGLT2i may slow valve degeneration by modulating SIRT1.

Cardiovascular Research · Sep 5, 2026Peer-reviewedCell Biology

Immortalization of human valve interstitial cells: an in vitro tool for studying fibro-calcific aortic valve degeneration

Donato Moschetta, Ilaria Massaiu, Francesca Bertolini, Vincenza Valerio, Valentina Rusconi, Donato De Giorgi, Veronika A. Myasoedova, Paolo Poggio

The paper immortalizes human valve interstitial cells to study fibro-calcific aortic valve degeneration and test drugs in vitro.

bioRxiv · Sep 26, 2024 · PreprintCell Biology

Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis

Nicolas Perrot, Donato Moschetta, S. Matthijs Boekholdt, Vincenza Valerio, Andreas Martinsson, Romain Capoulade, Elvira Mass, Marie-Annick A Clavel, Nicholas J. Wareham, Christian Dina C, Hao Yu Chen, James C. Engert, George Thanassoulis, Patrick Mathieu, Yohan Bossé, , Benoît J. Arsenault

This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.

bioRxiv · Mar 1, 2019 · PreprintGenetics