HP1 dimerization drives the condensation and segregation of H3K9me-marked chromatin
Karthik Eswara, Jennifer I. Semple, Francesca Rivas-Cuestas, Fernando Muzzopappa, Shakila Ali, Sonia El Mouridi, Yogesh B. Ostwal, Christian Frøkjær‐Jensen, Fabian Erdel, Peter Meister, Wolfgang Fischle
This study shows that HP1 dimerization drives H3K9me chromatin condensation and segregation, while LLPS stabilizes foci, and reveals a decoupling between heterochromatin and transcriptional regulation.
bioRxiv · Nov 13, 2025 · PreprintBiochemistry