Jennifer I. Semple

The paper identifies cohesin-dependent 3D chromatin structures called fountains around active enhancers in C. elegans, showing their role in repressing enhancer activity and linking genome architecture to behavior.

This study shows that HP1 dimerization drives H3K9me chromatin condensation and segregation, while LLPS stabilizes foci, and reveals a decoupling between heterochromatin and transcriptional regulation.

This study shows that condensin I/IDC, not cohesin, is the major genome loop extruder in C. elegans, leading to genome decompaction and loss of TAD structures.

The paper introduces RAPID, a method to determine tissue-specific transcriptional footprints in C. elegans without cell sorting, and validates it by identifying novel transcriptional profiles in rare cell types.