Ovarian Cancer Drives TLR5-Dependent Expansion of Myeloid Progenitors Through Systemic Dissemination of Ligands
Sree H. Kolli, Mitchell Thomas McGinty, Mirna Perusina Lanfranca, Cara N. Hatzinger, Audrey Marie Putelo, Mika K. Poblete, Simona Bajgai, Brandon A. Thompson, Tzu-Yu Feng, Francessca N Azar, Akshita Mirani, William A. Petri, Stacey L. Burgess, Melanie R. Rutkowski
This study shows ovarian cancer drives TLR5-dependent expansion of myeloid progenitors through systemic dissemination of ligands, leading to increased monocyte and macrophage accumulation in the tumor microenvironment.
Journal of Leukocyte Biology · Dec 5, 2025Peer-reviewedImmunology