This study shows that reducing DNA methyltransferase 1 in endothelial cells enhances anti-tumor immunity by altering the tumor microenvironment and improving immune cell infiltration.

Angiogenesis · May 19, 2026Peer-reviewedCancer Biology

Methanogenic archaea bolster mucosal homeostasis and protect from colitis

Emily E. Byrd, B. Harris, Hongpan Zhang, W Elise Warren, Sree H. Kolli, Audrey Marie Putelo, Mitchell Thomas McGinty, Michael D. Solga, Melanie R. Rutkowski, Melissa M. Kendall

This study shows that methanogenic archaea enhance intestinal epithelial regeneration, mucus production, and regulatory T cell accumulation, protecting against colitis.

bioRxiv · Jan 19, 2026 · PreprintMicrobiology

Ovarian Cancer Drives TLR5-Dependent Expansion of Myeloid Progenitors Through Systemic Dissemination of Ligands

Sree H. Kolli, Mitchell Thomas McGinty, Mirna Perusina Lanfranca, Cara N. Hatzinger, Audrey Marie Putelo, Mika K. Poblete, Simona Bajgai, Brandon A. Thompson, Tzu-Yu Feng, Francessca N Azar, Akshita Mirani, William A. Petri, Stacey L. Burgess, Melanie R. Rutkowski

This study shows ovarian cancer drives TLR5-dependent expansion of myeloid progenitors through systemic dissemination of ligands, leading to increased monocyte and macrophage accumulation in the tumor microenvironment.

Journal of Leukocyte Biology · Dec 5, 2025Peer-reviewedImmunology