Melanie R. Rutkowski

This study shows that combining focused ultrasound thermal ablation with CD40 agonism enhances tumor immunity, leading to durable regression and immunological memory in breast cancer models.

This study shows that reducing DNA methyltransferase 1 in endothelial cells enhances anti-tumor immunity by altering the tumor microenvironment and improving immune cell infiltration.

This study shows that methanogenic archaea enhance intestinal epithelial regeneration, mucus production, and regulatory T cell accumulation, protecting against colitis.

This study shows ovarian cancer drives TLR5-dependent expansion of myeloid progenitors through systemic dissemination of ligands, leading to increased monocyte and macrophage accumulation in the tumor microenvironment.

The paper identifies microbiome markers in primary colorectal cancer tumors that predict distant metastasis risk using cohort data and molecular techniques.

This study demonstrates that systemic chemotherapy can disrupt meningeal lymphatics, with differential effects observed between platinum and taxane chemotherapies.

This paper develops an ex vivo model of breast cancer cell invasion in live lymph node tissue, revealing preferential invasion patterns and immune-related resistance mechanisms.