Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength
Jennifer H. Kong, Cullen B. Young, Ganesh Varma Pusapati, F. Hernán Espinoza, Chandni B. Patel, Francis Beckert, Sebastian Ho, Bhaven B. Patel, George C. Gabriel, Lakshminarayanan Aravind, J. Fernando Bazán, Teresa M. Gunn, Cecilia W. Y. Lo, Rajat Rohatgi
The paper shows that gene-teratogen interactions affect birth defect penetrance by altering Hedgehog signaling through the MMM complex and SMO degradation.
Development · Sep 6, 2021Peer-reviewedDevelopmental Biology