Author

Sebastian Ho

University of PittsburghORCID 0000-0002-5947-9728Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Cecilia W. Y. LoiD· 2 shared Chandni B. PateliD· 2 shared Cullen B. YoungiD· 2 shared Ganesh Varma PusapatiiD· 2 shared Jennifer H. KongiD· 2 shared Lakshminarayanan AravindiD· 2 shared Rajat RohatgiiD· 2 shared Teresa M. GunniD· 2 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersDevelopmental Biology

Cecilia W. Y. LoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength

Jennifer H. Kong, Cullen B. Young, Ganesh Varma Pusapati, F. Hernán Espinoza, Chandni B. Patel, Francis Beckert, Sebastian Ho, Bhaven B. Patel, George C. Gabriel, Lakshminarayanan Aravind, J. Fernando Bazán, Teresa M. Gunn, Cecilia W. Y. Lo, Rajat Rohatgi

The paper shows that gene-teratogen interactions affect birth defect penetrance by altering Hedgehog signaling through the MMM complex and SMO degradation.

Development · Sep 6, 2021Peer-reviewedDevelopmental Biology

A ubiquitin-based mechanism for the oligogenic inheritance of heterotaxy and heart defects

Jennifer H. Kong, Cullen B. Young, Ganesh Varma Pusapati, Chandni B. Patel, Sebastian Ho, Arunkumar Krishnan, Jiuann-Huey Ivy Lin, William H. Devine, Anne Moreau de Bellaing, Tejas S. Athni, Lakshminarayanan Aravind, Teresa M. Gunn, Cecilia W. Y. Lo, Rajat Rohatgi

This study identifies a ubiquitin-based genetic mechanism linking Megf8 and Mgrn1 mutations to congenital heart defects and heterotaxy through altered Hedgehog signaling.

bioRxiv · May 25, 2020 · PreprintDevelopmental Biology