The Mechanism of Histone Ubiquitylation by the ASB9-CUL5 Ubiquitin Ligase
Calvin P. Lin, Nathan H. Lee, Francis X. Alipranti, Harry Li, Elizabeth A. Komives
This paper shows that the ASB9-CRL ubiquitin ligase polyubiquitylates histones H3 and H4, but not H2A and H2B, and that this process requires ARIH2 and occurs only on free histones.
Molecular & Cellular Proteomics · Nov 20, 2025Peer-reviewedBiochemistry