Francisco J. Acosta

This paper shows that metabolic overflow, such as acetate excretion, prevents ecological collapse in microbial populations by slowing growth and coordinating population responses.

This study shows the complement system actively regulates red blood cell mortality during immune responses to optimize blood flow and tissue perfusion.

This paper challenges the conventional view of HIFs as mediators of hypoxic stress, proposing instead that HIFs prevent hypoxia by regulating electron transport and redefining the Warburg effect as a homeostatic response to metabolic demand.

This paper introduces a modeling framework for homeostatic regulation that integrates biological context and signal dynamics, challenging traditional engineering control theory approaches.