Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences
Gabriella Rita Pangilinan, Sagar Patil, Francisco Mires, George Ye, Victoria Bogomilova, Lorraine Tilley, Tali Goldkorn, Cassandra Joan McGill, Nina Ballou, Xue Li, Unmesh Jadhav, Bérénice Anath Benayoun, Yulia Shwartz
This study shows that sympathetic aging is reversible and sexually dimorphic, with male mice showing greater denervation due to gonadal influences and target environment changes.
bioRxiv · Sep 7, 2026 · PreprintDevelopmental Biology