George Ye

This study shows CDX2 organizes enhancer networks during intestinal development and regeneration, reusing fetal and adult programs to restore regional identity.

This study shows that sympathetic aging is reversible and sexually dimorphic, with male mice showing greater denervation due to gonadal influences and target environment changes.

This study identifies H3K27me3 as an epigenetic barrier that restricts intestinal stem cell transformation by maintaining enhancer repression and preventing fetal gene reactivation in colorectal cancer.

This study shows that redox balance, regulated by NOX1 and HIF1-IDH1 interactions, controls epithelial stem cell fate in the distal colon niche.

The paper shows how Cdx2 binds different DNA motifs in developing and adult cells, leading to distinct gene activation patterns through methylation-dependent and -independent mechanisms.