Cassandra Joan McGill

This study shows that sympathetic aging is reversible and sexually dimorphic, with male mice showing greater denervation due to gonadal influences and target environment changes.

This study tests if 17α-estradiol benefits APOE4 females similarly to males, finding limited CNS improvements but some metabolic benefits in APOE4 females.

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

The paper identifies sex-dimorphic gene expression patterns in mouse macrophages across niches, finding three consistently differentially expressed genes and female-biased pathways related to extracellular matrix components.

This study shows that 17α-estradiol improves aging outcomes in APOE4 mice more than APOE3 mice, suggesting a genotype-dependent benefit of the intervention.

Long-read sequencing of 81 human and mouse samples yields 200,000 full-length transcripts plus a triplet framework that separates promoter choice, splicing and 3' end use across tissues.

The paper introduces LR-Split-seq, a long-read single-cell RNA-seq method, to study differential RNA isoform expression and validates it using mouse myoblast differentiation data.

The paper identifies muscle group-specific transcriptomic and DNA methylation differences in FSHD that relate to developmental patterning and disease susceptibility.

The paper compares chromatin dynamics during stem cell differentiation in human and rat, finding higher conservation in definitive endoderm than neuronal progenitor cells.

The paper identifies gene regulatory networks driving macrophage polarization using bulk and single-cell RNA-seq and ATAC-seq data from HL-60-derived macrophages.

This study compares gene expression in head and tail regions of Steinernema carpocapsae and Caenorhabditis elegans, identifying conserved and species-specific patterns in metabolism, development, and neuronal processes.

This paper introduces Long-TUC-seq, a method combining metabolic labeling with long-read sequencing to reliably detect isoform-level transcription dynamics.

The paper assembles the genome of Steinernema carpocapsae using long-read sequencing and optical mapping, identifies the X-chromosome, and provides gene annotations for comparative genomic studies.