Redox-regulated cysteine acylation governs β-lactam sensing by the Vibrio histidine kinase VbrK
Ignacio Guido Palanca, Irina P. Suárez, María J. Marcaida, Luciano A. Abriata, Natalia Gasilova, Laure Menin, Franco Emanuel Lacava, Julieta Cairoli, Matteo Dal Peraro, Leticia Irene Llarrull
This study reveals how β-lactam antibiotics interact with the histidine kinase VbrK through redox-dependent cysteine acylation, enabling bacterial resistance.
bioRxiv · Jun 9, 2026 · PreprintMicrobiology