Pharmacodynamic Markers of LRRK2 Inhibition in Biofluids
Shijie Wang, Kaela Kelly, Nathalie Schussler, Sylviane Boularand, Laurent Dubois, Frank Hsieh, Elizabeth Tengstrand, Jonathan M. Brotchie, James B. Koprich, Andrew B. West
This study identifies biofluid markers of LRRK2 inhibition in non-human primates using three LRRK2 inhibitors, showing reduced pS935-LRRK2 and exosome LRRK2 in blood, urine, and CSF.
bioRxiv · Jan 28, 2020 · PreprintNeuroscience