Author

Jonathan M. Brotchie

Atuka (Canada)ORCID 0000-0003-2337-0816Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

James B. KoprichiD· 2 shared Andrew B. WestiD· 1 shared Danny Ben‐ZviiD· 1 shared Elizabeth Tengstrand· 1 shared Frank Hsieh· 1 shared Hadar Arien‐ZakayiD· 1 shared Jochen RoeperiD· 1 shared Joshua A. GoldbergiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

James B. KoprichORCID

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2 papers

Recent·Most cited

NeuroscienceScience AdvancesPeer-reviewedMar 10, 2021

α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons causes non-motor parkinsonian symptoms

Wei‐Hua Chiu, Lora Kovacheva, Ruth E. Musgrove…·Joshua A. Goldberg

This study identifies a Kv4 channelopathy in mouse vagal motoneurons caused by α-synuclein overexpression, leading to impaired gastrointestinal motility as a non-motor prodromal symptom of Parkinson's disease.

18 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJan 28, 2020

Pharmacodynamic Markers of LRRK2 Inhibition in Biofluids

Shijie Wang, Kaela Kelly, Nathalie Schussler…·Andrew B. West

This study identifies biofluid markers of LRRK2 inhibition in non-human primates using three LRRK2 inhibitors, showing reduced pS935-LRRK2 and exosome LRRK2 in blood, urine, and CSF.

1 citation

non-human primateproteomics

𝕏 PostBluesky