Author

Kaela Kelly

Duke UniversityORCID 0000-0002-3313-9768Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Andrew B. WestiD· 4 shared Sylviane BoularandiD· 2 shared An Phu Tran Nguyen· 1 shared Arpine SokratianiD· 1 shared Ashley S. HarmsiD· 1 shared Aubrey M SchonhoffiD· 1 shared Baraa A. HijaziD· 1 shared Charlotte F. BrzozowskiiD· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersNeuroscience

Andrew B. WestORCID

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4 papers

Recent·Most cited

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Charlotte F. Brzozowski, Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, Laura A. Volpicelli‐Daley

This study shows that inhibiting LRRK2 kinase activity increases α-synuclein presynaptic localization and anterograde axonal transport in neurons.

Acta Neuropathologica Communications · Nov 8, 2021Peer-reviewedNeuroscience

Dopaminergic Neurodegeneration Induced by Parkinson's Disease-Linked G2019S LRRK2 is Dependent on Kinase and GTPase Activity

An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan D. Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barnéoud, Darren J. Moore

This study develops a rat model of Parkinson's disease caused by the G2019S LRRK2 mutation and shows that kinase and GTPase activities are critical for neurodegeneration.

Proceedings of the National Academy of Sciences · Jul 6, 2020Peer-reviewedNeuroscience

Pathologic α-Synuclein Species Activate LRRK2 in Pro-Inflammatory Monocyte and Macrophage Responses

Enquan Xu, Ravindra Boddu, Hisham Abdelmotilib, Kaela Kelly, Arpine Sokratian, Ashley S. Harms, Aubrey M Schonhoff, Nicole Bryant, Irene E. Harmsen, Michael G. Schlossmacher, Sidhanth Chandra, Valentina Krendelshchikova, Zhiyong Liu, Andrew B. West

The paper shows that α-synuclein fibrils activate LRRK2 kinase in monocyte-derived macrophages, linking LRRK2 mutations to pro-inflammatory responses in Parkinson's disease.

bioRxiv · May 4, 2020 · PreprintNeuroscience

Pharmacodynamic Markers of LRRK2 Inhibition in Biofluids

Shijie Wang, Kaela Kelly, Nathalie Schussler, Sylviane Boularand, Laurent Dubois, Frank Hsieh, Elizabeth Tengstrand, Jonathan M. Brotchie, James B. Koprich, Andrew B. West

This study identifies biofluid markers of LRRK2 inhibition in non-human primates using three LRRK2 inhibitors, showing reduced pS935-LRRK2 and exosome LRRK2 in blood, urine, and CSF.

bioRxiv · Jan 28, 2020 · PreprintNeuroscience