Author

Sylviane Boularand

Sanofi (France)ORCID 0000-0002-1403-5795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Andrew B. WestiD· 2 shared Kaela KellyiD· 2 shared An Phu Tran Nguyen· 1 shared Darren J. MooreiD· 1 shared Elizabeth Tengstrand· 1 shared Elpida TsikaiD· 1 shared Frank Hsieh· 1 shared James B. KoprichiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Andrew B. WestORCID

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2 papers

Recent·Most cited

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedJul 6, 2020

Dopaminergic Neurodegeneration Induced by Parkinson's Disease-Linked G2019S LRRK2 is Dependent on Kinase and GTPase Activity

An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly…·Darren J. Moore

This study develops a rat model of Parkinson's disease caused by the G2019S LRRK2 mutation and shows that kinase and GTPase activities are critical for neurodegeneration.

70 citationstop 3%

ratexperimental assay

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NeurosciencebioRxivPreprintJan 28, 2020

Pharmacodynamic Markers of LRRK2 Inhibition in Biofluids

Shijie Wang, Kaela Kelly, Nathalie Schussler…·Andrew B. West

This study identifies biofluid markers of LRRK2 inhibition in non-human primates using three LRRK2 inhibitors, showing reduced pS935-LRRK2 and exosome LRRK2 in blood, urine, and CSF.

1 citation

non-human primateproteomics

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