Reduction of HDAC2 expression in human induced pluripotent stem cell derived neurons improves neuronal maturation, mitochondrial dynamics and cellular neurodegenerative disease phenotypes.
Harald Frankowski, Fred Yeboah, Bonnie J. Berry, Chizuru Kinoshita, Michelle Lee, Kira M. Evitts, Joshua Davis, Yoshito Kinoshita, Richard S. Morrison, Jessica E. Young
This study shows that reducing HDAC2 in hiPSC-derived neurons enhances mitochondrial function and reduces neurotoxic amyloid beta, suggesting HDAC2's role in neuronal maturation and disease.
International Journal of Molecular Sciences · Mar 3, 2021Peer-reviewedNeuroscience