Jessica E. Young

ADVISE identifies context-specific Alzheimer's disease progression signatures using an explainable AI framework and validates ROBO2 as a candidate regulator in excitatory neurons.

This study shows that SORL1 deficiency in neurons alters synaptic protein interactions, causes hyperexcitability, and impairs synaptic plasticity, linking endosomal recycling defects to Alzheimer's disease pathogenesis.

The paper investigates how sex chromosome aneuploidy affects gene expression and DNA methylation in different cell types, revealing cell-type specific dosage compensation mechanisms.

Pharmacological inhibition of RhoGEF12 increases endosomal SORL1-retromer recycling and reduces pathogenic amyloid secretion in human neuronal models, identifying a novel, targetable pathway for treating Alzheimer's disease.

This study develops 2D and 3D human in vitro neurovascular unit models to investigate microglial interactions with endothelial cells and their role in neurovascular function under inflammatory conditions.

ACE identifies universal aging signatures across species by disentangling aging-related gene expression from other biological variations using explainable AI.

The paper compares the transcriptome of Kat5 knockout mice to AD datasets, finding similar gene expression patterns and showing KAT5 localization in AD neurons.

This study investigates ZIKV infection in fetal brain tissue, identifying astrocyte immune responses and neuronal dysfunction linked to congenital Zika syndrome.

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

This study shows that SORL1 deficiency in human microglia leads to lysosomal dysfunction, including impaired degradation and enzyme activity, contributing to Alzheimer's disease pathogenesis.

This study shows that genetic risk variants in endolysosomal network genes correlate with endolysosomal dysfunction in neural cells in Alzheimer's disease.

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

This paper introduces a new fluorescent sensor, oROS-HT, for real-time H2O2 monitoring with subcellular resolution and multi-parametric imaging capabilities.

This paper develops a fast, sensitive genetically encoded H2O2 sensor (oROS-G) and demonstrates its use in monitoring H2O2 dynamics in various cell types and models.

The paper identifies a pathogenic SORL1 variant, p.R953C, associated with Alzheimer's Disease and shows it impairs protein maturation and endosomal sorting.

The paper identifies transcriptomically distinct microglia populations in Alzheimer's disease and aged human brains using single-nucleus RNA-seq and trajectory inference.

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

The paper tests if a retromer stabilizing drug, TPT-260, can correct endosomal and Alzheimer's-related pathologies in neurons with SORL1 variants.

The paper compiles an annotated set of 171 small molecule modulators targeting 98 novel AD therapeutic proteins, serving as chemical tools for hypothesis validation.

This study shows that reducing HDAC2 in hiPSC-derived neurons enhances mitochondrial function and reduces neurotoxic amyloid beta, suggesting HDAC2's role in neuronal maturation and disease.