Ryanodine receptor 1 is dispensable for CD4+ T-cell differentiation and effector function in intestinal inflammation models
Sogol Dostiar Tabrizi, Mikołaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn‐Philipp Diercks, Nicola Gagliani, Dmitri Lodygin, Alexander Flügel, Andreas H. Guse, Hans‐Willi Mittrücker, Samuel Huber
This study shows that RYR1 in CD4+ T cells is not essential for their pathogenicity in intestinal inflammation models despite affecting calcium signaling.
European Journal of Immunology · Aug 1, 2026Peer-reviewedImmunology