TROP2-targeting chimeras (TRTACs) for tumor-selective membrane protein degradation and enhanced drug delivery
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Lixin Zhang
This paper introduces TRTACs, TROP2-targeting chimeras that selectively degrade tumor membrane proteins and deliver drugs, showing efficacy against EGFR and HER2-positive tumors with minimal toxicity.
bioRxiv · Aug 20, 2026 · PreprintCell Biology