Shiqun Shao

This paper introduces TRTACs, TROP2-targeting chimeras that selectively degrade tumor membrane proteins and deliver drugs, showing efficacy against EGFR and HER2-positive tumors with minimal toxicity.

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

This study develops a non-invasive HA delivery system using zwitterionic nanogels that improve skin hydration and reduce wrinkles in mice.