Lixin Zhang

This paper introduces TRTACs, TROP2-targeting chimeras that selectively degrade tumor membrane proteins and deliver drugs, showing efficacy against EGFR and HER2-positive tumors with minimal toxicity.

TRACER predicts terpene skeletal rearrangements by learning enzyme-product associations, identifying novel carbon skeletons and mechanistic insights.

This paper develops a two-stage fermentation system using Clostridium pasteurianum and Rhodobacter sphaeroides to enhance hydrogen production while reducing inhibitory metabolite accumulation.

This paper enhances CoQ10 production in Rhodobacter sphaeroides by engineering the PrrAB system and stabilizing the strain through CRISPRi, achieving 3.6 g/L in pilot-scale fermentation.

Yeast9 improves yeast metabolic modeling by integrating multi-omics data, showing better prediction of growth rates and gene function than transcriptomics.

The paper develops a method to efficiently clone large GC-rich BGCs from Streptomyces genomes using a CRISPR/Cas12a-based system, demonstrating its effectiveness with a 87-kb BGC.