Kinetic and Redox Characterization of KRAS G12C Inhibition
M. V. Huynh, D. Parsonage, T. E. Forshaw, V. R. Chirasani, G. A. Hobbs, H. Wu, J. Lee, C. M. Furdui, L. B. Poole, S. L. Campbell
This study characterizes the kinetic and redox properties of KRASG12C inhibition, revealing pH-dependent covalent ligation and oxidation effects on protein conformation.
bioRxiv · Apr 3, 2022Biochemistry