C. M. Furdui

Absence of CD47 in the tumor microenvironment modulates tumor metabolism and immunosuppressive signatures limiting breast cancer progression.

This paper shows that CD47 absence in tumors reduces tumor burden and enhances immune response by altering metabolism and immunosuppressive signatures in breast cancer.

Amino acid supplementation confers protection to red blood cells prior to Plasmodium falciparum bystander stress

The paper shows that amino acid supplementation protects red blood cells from oxidative stress caused by Plasmodium falciparum conditioned media.

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance

The paper shows that mitochondrial H2O2 oxidizes H3.1 at Cys96, promoting chromatin remodeling, breast cancer metastasis, and drug resistance.

ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice

This study shows ABHD4 promotes adipocyte differentiation in vitro but does not affect adipose lipid metabolism in mice despite high fat diet.

Kinetic and Redox Characterization of KRAS G12C Inhibition

This study characterizes the kinetic and redox properties of KRASG12C inhibition, revealing pH-dependent covalent ligation and oxidation effects on protein conformation.

DCP, First Generation PET Radiotracer for Diagnosis of Radiation Resistant Head and Neck Cancer

The study introduces a new PET radiotracer for profiling tumor protein oxidation as a prognostic indicator of resistance to radiation therapy.