Author

L. B. Poole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. M. Furdui· 2 shared H. Wu· 2 shared T. E. Forshaw· 2 shared A. W. Tsang· 1 shared C. E. McCall· 1 shared C. Zhu· 1 shared D. L. Long· 1 shared D. Parsonage· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

C. M. Furdui

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Author profile →

3 papers

Recent·Most cited

Glutathionylation of Pyruvate Dehydrogenase Complex E2 and Inflammatory Cytokine Production During Acute Inflammation Are Magnified By Mitochondrial Oxidative Stress

D. L. Long, C. E. McCall, L. B. Poole

This study shows that LPS-induced glutathionylation of PDCE2 in monocytes increases ROS production and alters cytokine profiles, with synergistic effects when combined with mitochondrial oxidative stress.

bioRxiv · Jan 26, 2023Immunology

Kinetic and Redox Characterization of KRAS G12C Inhibition

M. V. Huynh, D. Parsonage, T. E. Forshaw, V. R. Chirasani, G. A. Hobbs, H. Wu, J. Lee, C. M. Furdui, L. B. Poole, S. L. Campbell

This study characterizes the kinetic and redox properties of KRASG12C inhibition, revealing pH-dependent covalent ligation and oxidation effects on protein conformation.

bioRxiv · Apr 3, 2022Biochemistry

DCP, First Generation PET Radiotracer for Diagnosis of Radiation Resistant Head and Neck Cancer

X. Chen, K. Kumar Solingapuram Sai, Z. Li, C. Zhu, K. Shukla, T. E. Forshaw, H. Wu, S. Vance, M. Madonna, M. W. Dewhirst, A. W. Tsang, L. B. Poole, N. Ramanujam, S. B. King, C. M. Furdui

The study introduces a new PET radiotracer for profiling tumor protein oxidation as a prognostic indicator of resistance to radiation therapy.

bioRxiv · Apr 28, 2020 · PreprintCancer Biology