Author

G. Akanuma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:biophysical modeling· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Garcia-Pino· 2 shared H. Takada· 2 shared M. Roghanian· 2 shared R. Murayama· 2 shared V. Hauryliuk· 2 shared F. Trebini· 1 shared G. C. Atkinson· 1 shared I. Dzhygyr· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

A. Garcia-Pino

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The C-terminal RRM/ACT domain is crucial for fine-tuning the activation of 'long' RelA-SpoT Homolog enzymes by ribosomal complexes

H. Takada, M. Roghanian, V. Murina, I. Dzhygyr, R. Murayama, G. Akanuma, G. C. Atkinson, A. Garcia-Pino, V. Hauryliuk

This study shows that the RRM domain in long RSH enzymes is essential for proper ribosome-mediated activation, preventing excessive (p)ppGpp production and cytotoxicity.

bioRxiv · Jan 23, 2020Biochemistry

Ribosome association primes the stringent factor Rel for recruitment of deacylated tRNA to ribosomal A-site

H. Takada, M. Roghanian, J. Caballero-Montes, K. Van Nerom, S. Jimmy, P. Kudrin, F. Trebini, R. Murayama, G. Akanuma, A. Garcia-Pino, V. Hauryliuk

The paper reveals how RelA/SpoT Homolog factor Rel in Bacillus subtilis detects amino acid starvation by interacting with deacylated tRNA on the ribosome, triggering (p)ppGpp synthesis.

bioRxiv · Jan 17, 2020 · PreprintBiochemistry